- Lions-Chiefs could be the sexiest matchup of Week 6 and has a prime-time stage.
- But Jags-Seahawks or 49ers-Bucs could actually prove the most highly competitive contests.
- Two more teams will be on their byes for Week 6.
Week 6 of the NFL’s 2025 regular-season schedule kicks off Thursday night, the heated NFC East rivalry between the Philadelphia Eagles and New York Giants resuming with both clubs trying to get back into the win column following defeats last weekend.
The league’s International Series resumes Sunday morning in London, former U.K. ambassador Woody Johnson’s winless New York Jets technically hosting the suddenly surging Denver Broncos at Tottenham Hotspur Stadium. That will launch a fairly pedestrian lineup of Sunday games – Seahawks-Jaguars and 49ers-Buccaneers appearing to be the best of the bunch.
“Sunday Night Football” will feature what once looked like – and still could be – a Super Bowl 60 preview as the scalding Detroit Lions, winners of four in a row, visit the floundering but perpetually dangerous Kansas City Chiefs.
The docket concludes with yet another Monday night doubleheader, Bills-Falcons and Bears-Commanders putting the finishing touches on this week’s menu.
(The Houston Texans and Minnesota Vikings will be off as the second round of byes kick in.)
How does it all unfold? USA TODAY Sports’ panel of NFL experts serve up their weekly selections and scores:
(Odds provided by BetMGM)
NFL Week 6 picks, predictions and odds
- Philadelphia Eagles at New York Giants
- Denver Broncos at New York Jets
- Dallas Cowboys at Carolina Panthers
- Los Angeles Chargers at Miami Dolphins
- Seattle Seahawks at Jacksonville Jaguars
- Cleveland Browns at Pittsburgh Steelers
- Los Angeles Rams at Baltimore Ravens
- Arizona Cardinals at Indianapolis Colts
- New England Patriots at New Orleans Saints
- Tennessee Titans at Las Vegas Raiders
- San Francisco 49ers at Tampa Bay Buccaneers
- Cincinnati Bengals at Green Bay Packers
- Detroit Lions at Kansas City Chiefs
- Buffalo Bills at Atlanta Falcons
- Chicago Bears at Washington Commanders